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However, this medicine does not take the place of rest, exercise, physical therapy, or other treatments that your doctor may recommend for your condition. Metaxalone is a skeletal muscle relaxant. It acts on the central nervous system … Skelaxin (metaxalone) is a muscle relaxant and is used in adjunct to physical therapy for treatment of painful muscle spasms. Medscape – Musculoskeletal pain-specific dosing for Skelaxin (DSC) (metaxalone), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. SKELAXIN ® (metaxalone) is available as an 800 mg oval, scored pink tablet. Chemically, metaxalone is 5- [ (3,5- dimethylphenoxy) methyl]-2-oxazolidinone. The empirical formula is C 12 H 15 NO 3, which corresponds to a molecular weight of 221.25. 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