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Bepreve is a highly selective, H1 receptor antagonist which is to be dosed twice per day. BEPREVE ® (bepotastine besilate ophthalmic solution) 1.5% is a histamine H 1 receptor antagonist indicated for the treatment of itching associated with signs and symptoms of allergic conjunctivitis. What is Bepreve? Bepreve (bepotastine besilate ophthalmic solution) is a brand-name histamine H1 receptor antagonist and anti-allergy eye drop that is used to treat allergic conjunctivitis in adults and pediatric patients 2 years of age and older. It is less commonly used than many alternatives because of the need for a prescription and the higher cost. Order Bepreve online today and save! Bepreve (Bepotastine Besilate Ophthalmic Solution 1.5%) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources. 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